The Solus 100 system is new technology that enables experimentation previously not practical. The original ideas for the platform came from discussions with leading researchers and pharmaceutical companies. We have already completed a number of studies and are currently running more to show the utility of this previously unavailable data.

In the lab, Solus Biosystems currently envisions the primary application for the Solus 100 system is to profile the effect of small molecules and environmental conditions on the conformation of proteins.

In drug development, promising candidates are currently selected by binding assays that measure the strength of the association of small molecules with proteins. The Solus 100 system can provide details of this binding by profiling the change in conformation of the protein induced by the drug. Profiling can be used to select candidate drugs and to group similar drug candidates

In general lab and pharmaceutical applications, the IR profiling assays are powerful tools that can be used over a wide range of activities:

      • primary research
      • drug discovery
      • diagnostic markers
      • clinical research
      • manufacturing and quality control.

The platform is particularly useful for providing molecular association information, specifically how proteins interact with other molecules and with other proteins. Applications here include:

The assays are non-invasive and label-free, enabling several molecular interactions to be investigated simultaneously in a single micro well. Each sample cassette contains an array of micro wells, enabling the user to investigate complex multi-molecule interactions in a native biological environment. Sophisticated software helps the user isolate interaction effects and classify behavioral groupings.

View printable page (PDF)